Molecular basis for potentiation of Cx36 gap junction channel conductance by n-alcohols and general anesthetics

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Molecular basis for potentiation of Cx36 gap junction channel conductance by n-alcohols and general anesthetics

In our recent study, we have demonstrated that short carbon chain n-alcohols (up to octanol) stimulated while long carbon chain n-alcohols inhibited the conductance of connexin (Cx) 36 (Cx36) gap junction (GJ) channels. In contrast, GJ channels composed of other types of Cxs all were inhibited by n-alcohols independent of their carbon chain length. To identify the putative structural domains of...

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ژورنال

عنوان ژورنال: Bioscience Reports

سال: 2018

ISSN: 0144-8463,1573-4935

DOI: 10.1042/bsr20171323